Preventing paracetamol overdose in children: do we really need a 500 mg/5mL preparation?
نویسندگان
چکیده
1. Mahajan V, Sajan SS, Sharma A, Kaur J. Ringers lactate vs normal saline for children with acute diarrhea and severe dehydrationA double blind randomized controlled trial. Indian Pediatr. 2012;49:963-8. 2. Vickers AJ. The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study. BMC Med Res Methodol. 2001;1:6. 3. Vickers AJ, Altman DG. Statistics notes: Analysing controlled trials with baseline and follow up measurements. BMJ. 2001;323:1123-4. 4. Van Breukelen GJ. ANCOVA versus change from baseline: more power in randomized studies, more bias in nonrandomized studies [corrected]. J Clin Epidemiol. 2006;59:920-5. 5. Begg CB. Suspended judgment. Significance tests of covariate imbalance in clinical trials. Control Clin Trials. 1990;11:223-5. 6. Senn S. Testing for baseline balance in clinical trials. Stat Med. 1994;13:1715-26.
منابع مشابه
Paracetamol--high strength formulations and toxicity.
In India, paracetamol is available in many formulations such as liquid suspension, drops, tablets, injection, rectal suppositories with varying concentrations (120/125/150/ 250/500 mg/5 mL). The usual cause of paracetamol overdose is frequent administration of the drug round the clock by an anxious parent who regards fever as a potential dangerous event and as a trigger for febrile seizures. Un...
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However, we disagree with Dr Lee that the toxicity should be attributed solely to rectal paracetamol. Firstly, the pharmacokinetics of rectal paracetamol have been extensively studied, and it has been suggested that even a rectal regimen of 25 mg/kg every 6 hours for a mean of 2 to 3 days did not result in supratherapeutic concentration. Secondly, because oral and rectal paracetamol are metabol...
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عنوان ژورنال:
- Indian pediatrics
دوره 50 5 شماره
صفحات -
تاریخ انتشار 2013